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OSM-S-106

Chemical Structure : OSM-S-106

CAS No.: 2650846-59-4

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OSM-S-106 (TCMDC-135294)

Catalog No.: PC-21022Not For Human Use, Lab Use Only.

OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.

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    Biological Activity

    OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.
    OSM-S-106 also prevents the development of P. berghei in liver cells (HepG2-A16-CD81-EGF; IC50 = 0.25/0.42 µM).
    OSM-S-106 exhibited low cytotoxicity against the HepG2 cell line.
    OSM-S-106 exhibits a low propensity for developing resistance.
    OSM-S-106 inhibits protein translation and induces the amino acid starvation response.
    OSM-S-106 inhibits ATP consumption by PfAsnRS but not HsAsnRS.

    Physicochemical Properties

    M.Wt 306.36
    Formula C12H10N4O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-aminothieno[3,2-d]pyrimidin-6-yl)benzenesulfonamide

    References

    1. Leann Tilley, et al. Res Sq. 2023 Jul 27;rs.3.rs-3198291.

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