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Chemical Structure : OSM-S-106
Catalog No.: PC-21022Not For Human Use, Lab Use Only.
OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.
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OSM-S-106 is a reaction hijacking inhibitor of Plasmodium falciparum asparagine tRNA synthetase (PfAsnRS), inhibits the 3D7 line of P. falciparum with IC50 of 58 nM.
OSM-S-106 also prevents the development of P. berghei in liver cells (HepG2-A16-CD81-EGF; IC50 = 0.25/0.42 µM).
OSM-S-106 exhibited low cytotoxicity against the HepG2 cell line.
OSM-S-106 exhibits a low propensity for developing resistance.
OSM-S-106 inhibits protein translation and induces the amino acid starvation response.
OSM-S-106 inhibits ATP consumption by PfAsnRS but not HsAsnRS.
| M.Wt | 306.36 | |
| Formula | C12H10N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leann Tilley, et al. Res Sq. 2023 Jul 27;rs.3.rs-3198291.
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