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Chemical Structure : ELQ-300
CAS No.: 1354745-52-0
Catalog No.: PC-20296Not For Human Use, Lab Use Only.
ELQ-300 (ELQ300) is a potent, selective inhibitor of P. falciparummitochondrial cytochrome bc1 complex with IC50 of 0.56 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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ELQ-300 (ELQ300) is a potent, selective inhibitor of P. falciparummitochondrial cytochrome bc1 complex with IC50 of 0.56 nM.
ELQ-300 is potent in vitro against blood stage P. falciparum strains including a clinical isolate with a mutation in the cytochrome b gene that is associated with atovaquone resistance.
ELQ-300 has high in vitro selectivity for P. falciparum bc1 complex over the human enzyme complex and various mammalian cell types including hematopoietic stem cells.
ELQ-300 does not inhibit human cytochrome bc1 (IC50>10 uM).
ELQ-300 inhibits P. falciparum-infected red blood cells with IC50 of 6 nM.
ELQ-300 is active against liver, blood, and transmission stages of Plasmodium falciparum.
| M.Wt | 475.85 | |
| Formula | C24H17ClF3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Chloro-7-methoxy-2-methyl-3-{4-[4-(trifluoromethoxy)phenoxy]phenyl}quinolin-4(1H)-one |
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1. Nilsen A, et al. Sci Transl Med. 2013 Mar 20;5(177):177ra37.
2. Miley GP, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60.
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