Cat. No. |
Product Name |
Information |
PC-72540 |
MMV084978
PfAcAS inhibitor
|
MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM. |
PC-72539 |
MMV019721
PfAcAS inhibitor
|
MMV019721 (MMV019721) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 73 nM. |
PC-72521 |
INE963
Antimalarial
|
INE963 (INE-963) is a potent and fast-acting blood-stage antimalarial, demonstrates potent cellular activity against Pf 3D7 with EC50 of 6 nM in Pf growth inhibition assay. |
PC-72407 |
CTN1122
L-CK1.2 inhibitor
|
CTN1122 (CTN-1122) is a potent, selective Leishmaniacasein kinase 1 isoform 2 (CK1.2, L-CK1.2) with IC50 of 0.72 uM (LmCK1) and 0.8 uM (amastigotes L. major), antileishmanial compound. |
PC-72339 |
MMV030084
Pf PKG inhibitor
|
MMV030084 (MMV-030084) is a potent, specific P. falciparum cGMP-dependent protein kinase (PKG) inhibitor (Kdapp=9-16 nM), inhibits invasion of P. berghei ANKA parasites into HepG2 liver cells with IC50 of 199 nM. |
PC-38234 |
Parabulin
Parasite tubulin inhibitor
|
Parabulin is a novel potent, parasite-specific tubulin inhibitor, inhibits growth of parasites while displaying no effects on human cells. |
PC-38084 |
ML251
T.bPFK inhibitor
|
ML251 is a potent, selective inhibitor of T. brucei phosphofructokinase (PFK) with IC50 of 15 nM. |
PC-38059 |
Selamectin
|
Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. |
PC-36167 |
GSK3494245
L. donovani proteasome inhibitor
|
GSK3494245 (DDD01305143, GSK-3494245) is a a preclinical candidate for Visceral leishmaniasis (VL) by inhibition of the chymotrypsin-like activity catalyzed by the β5 subunit of the L. donovani proteasome with IC50 of 0.16 uM. |
PC-35985 |
NEU-4438
Anti-parasite
|
NEU-4438 (NEU4438) is a potent inhibitor of P. falciparum with EC50 of 13 nM (T. brucei), demonstrates improved aqueous solubility (880 uM) compared to NEU-1953. |
PC-35984 |
NEU-1953
Anti-parasite
|
NEU-1953 (NEU1953) is a potent inhibitor of P. falciparum with EC50 of 0.43 uM (T. brucei), demonstrates improved ADME profile over the NEU-961.. |
PC-35930 |
HS220
PfPK9 inhibitor
|
HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum. |