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MMV084978

Chemical Structure : MMV084978

CAS No.: 252949-96-5

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MMV084978 (MMV 084978)

Catalog No.: PC-72540Not For Human Use, Lab Use Only.

MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.

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    Biological Activity

    MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.
    MMV084978 directly inhibits PfAcAS by preventing CoA and acetate binding.
    MMV084978 demonstrated in vitro efficacy (P. falciparum Dd2 EC50=150 nM) with increased liver-stage potency (Pbluc EC50= 520 nM).
    MMV084978 directly and selectively inhibit PfAcAS activity in vitro.

    Physicochemical Properties

    M.Wt 282.702
    Formula C10H7ClN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N'-(4-chlorobenzoyl)-1,2,3-thiadiazole-4-carbohydrazide

    References

    1. Robert L Summers, et al. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8.

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