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Chemical Structure : MMV084978
Catalog No.: PC-72540Not For Human Use, Lab Use Only.
MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.
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MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.
MMV084978 directly inhibits PfAcAS by preventing CoA and acetate binding.
MMV084978 demonstrated in vitro efficacy (P. falciparum Dd2 EC50=150 nM) with increased liver-stage potency (Pbluc EC50= 520 nM).
MMV084978 directly and selectively inhibit PfAcAS activity in vitro.
| M.Wt | 282.702 | |
| Formula | C10H7ClN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Robert L Summers, et al. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8.
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