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CTCB-405

Chemical Structure : CTCB-405

CAS No.: 2342614-58-6

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CTCB-405 (CTCB405)

Catalog No.: PC-72583Not For Human Use, Lab Use Only.

CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.
    CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).
    CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.

    Physicochemical Properties

    M.Wt 364.27
    Formula C18H19Cl2N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3,4-dichlorobenzyl)-5-(2-(dimethylamino)ethyl)-1,5-dihydro-4H-pyrrolo[3,2-c]pyridin-4-one

    References

    1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052.

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