| Cat. No. |
Product Name |
Information |
| PC-49830 |
TCMDC-136879
Antimalarial
|
TCMDC-136879 is a cyclic acyl guanidine compound with antimalarial activity. |
| PC-49829 |
WM382
Pf PMX inhibitor
|
WM382 (WM-382) is a potent, specific dual inhibitor of the aspartic proteases Plasmepsin IX and X (PMIX and PMX) with IC50 of 0.06 nM (PMX), blocks multiple stages of the Plasmodium life cycle. |
| PC-49827 |
UCB7362
Pf PMX inhibitor
|
UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM. |
| PC-49610 |
Halofuginone
PfcPRS inhibitor
|
Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM. |
| PC-49609 |
Febrifugine
PfcPRS inhibitor
|
Febrifugine is a quinazolinone alkaloid for treating malaria-induced fever for about 2000 years, targets the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS). |
| PC-49608 |
Halofuginol
PfcPRS inhibitor
|
Halofuginol (MAZ1805) is a halofuginone analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=71.1 nM), is highly active against both liver and asexual blood stages of the malaria parasite (EC50=5.8 nM, P. falciparum 3D7 parasite strain). |
| PC-49605 |
SCR0911
Cyt bc inhibitor
|
SCR0911 is a potent malarial cytochrome bc1 inhibitor, inhibits cell growth and ATP synthesis in both the fast- and slow-growing M. smegmatis and M. bovis bacillus Calmette-Guérin, respectively. |
| PC-49604 |
TBAJ-587
ATP synthase inhibitor
|
TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively, inhibits M. tuberculosis ATP synthase. |
| PC-49603 |
AWE402
Cyt bcc-aa3 inhibitor
|
AWE402 (AWE-402) is a small molecule inhibitor targeting M. tuberculosis cytochrome bcc-aa3 of the electron transport chain (ETC), shows MIC value of 5 nM activity against Mycobacterium tuberculosis H37Rv. |
| PC-49602 |
CK-2-63
Cyt bd inhibitor
|
CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM. |
| PC-49324 |
KNX-002
TgMyoA inhibitor
|
KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins. |
| PC-49323 |
KNX-115
PfMyoA inhibitor
|
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins. |
