Halofuginone (RU-19110)

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Chemical Structure : Halofuginone

CAS No.: 55837-20-2

Catalog No.: PC-49610Not For Human Use, Lab Use Only.

Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$428	In stock
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Biological Activity

Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM.

Physicochemical Properties

M.Wt	414.68
Formula	C16H17BrClN3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one

References

1. Jonathan D Herman, et al. Sci Transl Med. 2015 May 20;7(288):288ra77.

2. Jiang S, et al. Antimicrob. Agents Chemother. 2005;49:1169–1176.

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