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Chemical Structure : WM382
Catalog No.: PC-49829Not For Human Use, Lab Use Only.
WM382 (WM-382) is a potent, specific dual inhibitor of the aspartic proteases Plasmepsin IX and X (PMIX and PMX) with IC50 of 0.06 nM (PMX), blocks multiple stages of the Plasmodium life cycle.
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WM382 (WM-382) is a potent, specific dual inhibitor of the aspartic proteases Plasmepsin IX and X (PMIX and PMX) with IC50 of 0.06 nM (PMX), blocks multiple stages of the Plasmodium life cycle.
WM382 displays no activity against the P. falciparum aspartic protease PMV (>300,000-fold).
WM382 inhibits P. falciparum and P. knowlesi growth with EC50s of 0.6 nM and 0.2 nM, respectively.
WM382 is not cross-resistant to other antimalarial drugs (chloroquine, mefloquine, artemisinin, and atovaquone).
WM382 (2.5 nM) potently inhibited egress of merozoites from the erythrocyte.
WM382 (20 mpk, orally administered twice daily (b.i.d. dosage)) suppresses P. berghei and P. falciparum infection infection in mice infected models.
WM382 prevents transmission to mosquitoes and transition from liver to blood infection.
| M.Wt | 504.63 | |
| Formula | C29H36N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. de Lera Ruiz M, et al. ACS Med Chem Lett. 2022 Oct 12;13(11):1745-1754.
2. Favuzza P, et al. Cell Host Microbe. 2020 Apr 8;27(4):642-658.e12.
3. Hodder AN, et al. Structure. 2022 Jul 7;30(7):947-961.e6.
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