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CK-2-63

Chemical Structure : CK-2-63

CAS No.: 1361004-98-9

CK-2-63

Catalog No.: PC-49602Not For Human Use, Lab Use Only.

CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM.
    CK-2-63 potentiate and synergize the growth inhibition and bactericidal activity of known electron transport chain (ETC) inhibitors including Q203 and BDQ.

    Physicochemical Properties

    M.Wt 411.38
    Formula C23H16F3NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

    References

    1. Laura N Jeffreys, et al. ACS Infect Dis. 2023 Jan 6. doi: 10.1021/acsinfecdis.2c00283.

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