CK-2-63

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Chemical Structure : CK-2-63

Catalog No.: PC-49602Not For Human Use, Lab Use Only.

CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM.
CK-2-63 potentiate and synergize the growth inhibition and bactericidal activity of known electron transport chain (ETC) inhibitors including Q203 and BDQ.

Physicochemical Properties

M.Wt	411.38
Formula	C23H16F3NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methyl-2-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one

References

1. Laura N Jeffreys, et al. ACS Infect Dis. 2023 Jan 6. doi: 10.1021/acsinfecdis.2c00283.

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CK-2-63

Biological Activity

Physicochemical Properties

References

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