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Chemical Structure : KNX-002
Catalog No.: PC-49324Not For Human Use, Lab Use Only.
KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins.
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KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins.
KNX-002 has little to no detectable effect on the actin-activated ATPase activity of bovine cardiac myosin, chicken gizzard smooth muscle myosin, rabbit fast skeletal muscle myosin, or bovine slow skeletal muscle myosin at 40 uM.
KNX-002 inhibits parasite motility and growth in culture in a dose-dependent manner (IC50=19.7 uM), with no detectable toxicity to human cells.
The mutation TgMyoA (T130A) renders the motor less sensitive to KNX-002, parasites expressing the T130A mutation shows reduced sensitivity to KNX-002 in both motility and growth assays.
| M.Wt | 325.430 | |
| Formula | C18H19N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1, Moussaoui D, et al. Nat Commun. 2023 Jun 12;14(1):3463.
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