Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KNX-115
Catalog No.: PC-49323Not For Human Use, Lab Use Only.
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins.
| Packing | Price | Stock | Quantity |
|---|
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins.
KNX-115 inhibits the blood and liver stages of Plasmodium with an EC50 of 110 nM, with negligible liver cell toxicity.
KNX-115 inhibits sporozoite cell traversal and blocks the gametocyte to oocyst conversion in the mosquito.
NX-115 displays a similar killing profile to pyrimethamine and parasites are totally killed after 96 hours of treatment.
KNX-115 is equally effective at inhibiting a panel of Plasmodium strains resistant to experimental and marketed antimalarials.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
