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TBAJ-587

Chemical Structure : TBAJ-587

CAS No.: 2252316-16-6

TBAJ-587 (TBAJ587)

Catalog No.: PC-49604Not For Human Use, Lab Use Only.

TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively, inhibits M. tuberculosis ATP synthase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively, inhibits M. tuberculosis ATP synthase.
TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade.

Physicochemical Properties

M.Wt 614.51
Formula C30H33BrFN3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoro-3-methoxyphenyl)butan-2-ol

References

1. Lisa Barbaro, et al. ChemMedChem. 2022 Oct 19;e202200533.

2. Sutherland HS, et al. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307.

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