| Cat. No. |
Product Name |
Information |
| PC-49314 |
AN15368
Anti-parasite
|
AN15368 (AN 15368) is a small molecule prodrug activated by parasite carboxypeptidases to yield a compound that targets the messenger RNA processing pathway in Trypanosoma cruzi (T. cruzi), exhibits potent in vitro activity against T. cruzi with IC50 of 5 nM. |
| PC-49292 |
DDD01510706
PfKRS inhibitor
|
DDD01510706 is a small molecule inhibitor of PfKRS (Plasmodium falciparum Lysyl tRNA Synthetase) with pIC50 of 6.62, interacts with the ATP binding site of PfKRS, inhibits plasmodium falciparum asexual blood-stage (ABS) parasite strain Dd2 with EC50 of 0.3 uM. |
| PC-49283 |
T-3767758
ProRS inhibitor
|
T-3767758 is a potent, proline-uncompetitive inhibitor of prolyl-tRNA synthetase (ProRS), displays good activity with EC50 of 595 nM against P. falciparum Dd2-2D4 wild-type parasites. |
| PC-49005 |
MBX-4055
P. falciparum PSAC inhibitor
|
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes. |
| PC-49003 |
MBX-2366
P. falciparum PSAC inhibitor
|
MBX-2366 (ISG-21) is a potent and specific antimalarial compound with IC50 of 3 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=2 nM) to quantitatively abolish parasite-induced permeability changes. |
| PC-47070 |
NPD-001
TbrPDEB1 inhibitor
|
NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities. |
| PC-47069 |
NPD-008
TbrPDEB1 inhibitor
|
NPD-008 is a potent, selective Trypanosoma brucei PDE B1 (TbrPDEB1) inhibitor with Ki of 100 nM, exhibits antitrypanosomal effects with IC50 of 5.5 uM. |
| PC-47035 |
UBMC-4
T. cruzi inhibitor
|
UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL). |
| PC-47013 |
GNF179
Antimalarial
|
GNF179 is an antimalarial imidazolopiperazine, possesses low nanomolar potency against P. falciparum liver stages, asexual blood stages and sexual stage gametocytes. |
| PC-38663 |
MMV665916
PfFT inhibitor
|
MMV665916 is potential antimalarial agent targeting the P. falciparum farnesyltransferase (PfFT), shows remarkable growth inhibition with EC50 value of 0.4 uM. |
| PC-38540 |
Soporidine
|
Soporidine is a small-molecule antagonist of germination of the parasitic plant Striga hermonthica, specifically inhibits S. hermonthica strigolactone receptor and inhibits the parasite germination, disrupting the Striga lifecycle. |
| PC-38537 |
NCGC00262650
AMA1-RON2 inhibitor
|
NCGC00262650 is a small molecule merozoite invasion inhibitor inhibitor of parasite AMA1-RON2 interaction, blocks entry of merozoites into RBCs with IC50 of 9.8 uM. |
