Catalog No.: PC-20446Not For Human Use, Lab Use Only.
Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).
Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).
Nemacol-1 can suppress the paralysis induced by two structurally distinct AChE inhibitors, namely trichlorfon (an organophosphate) and aldicarb (a carbamate) in a dose-dependent manner.
Nemacol-1 is 5.4-fold more potent than Vesamicol in live C. elegans worms, but has 37-fold less affinity than Vesamicol for the mammalian VAChT target (Ki=875 nM, rat VAChT).
Nemacol-1 enhances the ability of the anthelmintic Ivermectin to paralyze C. elegans and the ruminant nematode parasite Haemonchus contortus.
Physicochemical Properties
M.Wt
303.41
Formula
C17H25N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(cyclohexylmethyl)-4-(4-nitrophenyl)piperazine
References
1. Harrington S, et al. Nat Commun. 2023 Mar 31;14(1):1816.
