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Chemical Structure : Nemacol-1
Catalog No.: PC-20446Not For Human Use, Lab Use Only.
Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).
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Nemacol-1 is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter (VAChT), demonstrates nematode-selective activity (C. elegans, EC50=7.1 uM).
Nemacol-1 can suppress the paralysis induced by two structurally distinct AChE inhibitors, namely trichlorfon (an organophosphate) and aldicarb (a carbamate) in a dose-dependent manner.
Nemacol-1 is 5.4-fold more potent than Vesamicol in live C. elegans worms, but has 37-fold less affinity than Vesamicol for the mammalian VAChT target (Ki=875 nM, rat VAChT).
Nemacol-1 enhances the ability of the anthelmintic Ivermectin to paralyze C. elegans and the ruminant nematode parasite Haemonchus contortus.
| M.Wt | 303.41 | |
| Formula | C17H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harrington S, et al. Nat Commun. 2023 Mar 31;14(1):1816.
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