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GW844520

Chemical Structure : GW844520

CAS No.: 137735-25-2

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GW844520 (GW 844520)

Catalog No.: PC-20293Not For Human Use, Lab Use Only.

GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.
    GW844520 shows weak inhibition for cytochrome bc1 from HEK293 cells with IC50 of 300 nM (>100-fold selectivity).
    GW844520 displays potent antimalarial activity against Plasmodium falciparumin vitro (P. falciparum 3D7A, IC50=5 nM, whole cell assay).

    Physicochemical Properties

    M.Wt 409.79
    Formula C20H15ClF3NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-2,6-dimethyl-5-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one

    References

    1. Capper MJ, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60.

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