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Chemical Structure : GW844520
Catalog No.: PC-20293Not For Human Use, Lab Use Only.
GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.
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GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.
GW844520 shows weak inhibition for cytochrome bc1 from HEK293 cells with IC50 of 300 nM (>100-fold selectivity).
GW844520 displays potent antimalarial activity against Plasmodium falciparumin vitro (P. falciparum 3D7A, IC50=5 nM, whole cell assay).
| M.Wt | 409.79 | |
| Formula | C20H15ClF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Capper MJ, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60.
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