ML276 | PfG6PDH inhibitor | Probechem Biochemicals

Chemical Structure : ML276

ML276 (ML 276)

Catalog No.: PC-20587Not For Human Use, Lab Use Only.

ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.

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Biological Activity

ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.
ML276 inhibits P. falciparum growth in vitro with IC50 values of 2.3 uM for the chloroquine sensitive 3D7 strain and 3.7 uM for the chloroquine resistant Dd2 strain.
ML276 inhibits PfGluPho activity by competing with the substrate.

Physicochemical Properties

M.Wt	425.52
Formula	C23H24FN3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC=C(C(NC/2=O)=C1)SC2=C/C3=CC=CC=C3F)NC[C@@H]4N(CC)CCC4

References

1. Preuss J, et al. J Med Chem. 2012 Aug 23;55(16):7262-72.

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ML276 (ML 276)

Biological Activity

Physicochemical Properties

References

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