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ML276

Chemical Structure : ML276

CAS No.: 1392138-96-3

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ML276 (ML 276)

Catalog No.: PC-20587Not For Human Use, Lab Use Only.

ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.
    ML276 inhibits P. falciparum growth in vitro with IC50 values of 2.3 uM for the chloroquine sensitive 3D7 strain and 3.7 uM for the chloroquine resistant Dd2 strain.
    ML276 inhibits PfGluPho activity by competing with the substrate.

    Physicochemical Properties

    M.Wt 425.52
    Formula C23H24FN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    O=C(C1=CC=C(C(NC/2=O)=C1)SC2=C/C3=CC=CC=C3F)NC[C@@H]4N(CC)CCC4

    References

    1. Preuss J, et al. J Med Chem. 2012 Aug 23;55(16):7262-72.

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