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Chemical Structure : ML304
Catalog No.: PC-20586Not For Human Use, Lab Use Only.
ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM).
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ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM).
ML304 inhibits Plasmodium vivax G6PD (PvG6PD) with IC50 of 15.3 uM.
ML304 acts as a competitive inhibitor towards G6P (Ki =0.7 µM) and as a mixed type inhibitor towards NADP+ (Ki =16.3 µM).
ML304 disturbs the cytosolic glutathione-dependent redox potential of P. falciparum blood stage parasites, inhibits P. falciparum 3D7 in the 72 h hypoxanthine incorporation assays with IC50 of 471 nM.
| M.Wt | 395.52 | |
| Formula | C22H25N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maloney P, et al. NIH, Bethesda, MD.
2. Kristina Haeussler, et al. Malar J. 2019 Jan 25;18(1):22.
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