WHZ-04

Chemical Structure : WHZ-04

Catalog No.: PC-27569Not For Human Use, Lab Use Only.

WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7.

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Biological Activity

Physicochemical Properties

M.Wt	488.60
Formula	C24H32N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N1-(2-benzamidoethyl)-N4-(tert-butyl)-2-((4-methylphenyl)sulfonamido)succinamide

References

1. Wenhu Zhan, et al. J Med Chem. 2019 Jul 11;62(13):6137-6145.

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WHZ-04

Biological Activity

Physicochemical Properties

References

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