Chemical Structure : UCB-9721
CAS No.:
UCB-9721
(UCB9721)
Catalog No.: PC-27175Not For Human Use, Lab Use Only.
UCB-9721 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 31 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCB-9721 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 31 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity.
UCB-9721 also inhibits TgMyoA motor function in an in vitro motility assay
UCB-9721 inhibits T. gondii parasite motility with IC50 of 0.139 uM, with no detectable toxicity towards mammalian cells.
UCB-9721 inhibits the growth of T. gondii in human foreskin fibroblasts (HFFs) with an IC50 of 2.488 uM.
UCB-9721 also inhibits the motility and/or growth of the related apicomplexan parasites Plasmodium falciparum, Cryptosporidium parvum, and Babesia duncani.
Physicochemical Properties
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M.Wt
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387.45
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Formula
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C19H21N3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((3-(4-ethoxyphenyl)-1H-pyrazol-4-yl)methyl)-4-methoxybenzenesulfonamide
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References
1. Anne K Snyder, et al. bioRxiv [Preprint]. 2026 Jun 19:2026.06.18.733251.
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