Chemical Structure : BKI-1708
CAS No.:
2332840-70-5
BKI-1708
(BKI 1708)
Catalog No.: PC-25200Not For Human Use, Lab Use Only.
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays.
BKI-1708 is active against C. parvum and C. hominis parasites with EC50 of 0.05-0.2 uM.
BKI-1708 (8 mg/kg QD, oral) exhibited efficacy in a mouse model of Cryptosporidium infection.
Physicochemical Properties
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M.Wt
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394.48
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Formula
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C22H26N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-amino-3-(6-cyclopropoxynaphthalen-2-yl)-1-(3-hydroxy-2,2-dimethylpropyl)-1H-pyrazole-4-carboxamide
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References
1. Hulverson MA, et al. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0142522.
2. Choi R, et al. PLoS Negl Trop Dis. 2025 Jul 30;19(7):e0013263.
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