Chemical Structure : ELQ-316
CAS No.:
1354745-69-9
ELQ-316
(ELQ316)
Catalog No.: PC-24760Not For Human Use, Lab Use Only.
ELQ-316 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.007 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ELQ-316 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.007 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.
ELQ-316 has ED(50) value of 0.08 mg/kg when administered orally to mice with acute toxoplasmosis.
ELQ-316 is highly active against the cyst form of T. gondii in mice at low doses, reducing cyst burden by 76-88% after 16 d of treatment.
Physicochemical Properties
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M.Wt
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459.40
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Formula
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C24H17F4NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4(1H)-Quinolinone, 6-fluoro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-
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References
1. Doggett JS, et al. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.
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