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NEU-4438

Chemical Structure : NEU-4438

CAS No.: 2306305-57-5

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NEU-4438 (NEU4438)

Catalog No.: PC-35985Not For Human Use, Lab Use Only.

NEU-4438 (NEU4438) is a potent inhibitor of P. falciparum with EC50 of 13 nM (T. brucei), demonstrates improved aqueous solubility (880 uM) compared to NEU-1953.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NEU-4438 (NEU4438) is a potent inhibitor of P. falciparum with EC50 of 13 nM (T. brucei), demonstrates improved aqueous solubility (880 uM) compared to NEU-1953.
    NEU-4438 reduced parasitemia 109 fold in trypanosome-infected mice.

    Physicochemical Properties

    M.Wt 426.528
    Formula C24H26N8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-1-methyl-7-(2-(4-methyl-1,4-diazepan-1-yl)pyrimidin-5-yl)-N-(pyrazin-2-yl)quinolin-4(1H)-imine

    References

    1. Mehta N, et al. ACS Infect Dis. 2018 Apr 13;4(4):577-591.

    2. Bachovchin KA, et al. J Med Chem. 2018 Dec 19. doi: 10.1021/acs.jmedchem.8b01365.

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