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Chemical Structure : EDI048
CAS No.: 2767264-57-1
Catalog No.: PC-23131Not For Human Use, Lab Use Only.
EDI048 (EDI-048) is a specific, ATP-competitive, gastrointestinal-targeted Cryptosporidium PI(4)K (CpPI(4)K) inhibitor with IC50 of 4 nM, >300-fold with human orthologue HsPI(4)K, demonstrates in vitro anti-Cryptosporidium activity (Cp CPE, EC50=52 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EDI048 (EDI-048) is a specific, ATP-competitive, gastrointestinal-targeted Cryptosporidium PI(4)K (CpPI(4)K) inhibitor with IC50 of 4 nM, >300-fold with human orthologue HsPI(4)K, demonstrates in vitro anti-Cryptosporidium activity (Cp CPE, EC50=52 nM).
EDI048 is a potent CpPI(4)K inhibitor (IC50 = 5.2 nM) with anti-parasitic activity against both C. parvum and C. hominis, is active on Cryptosporidium in the gastrointestinal epithelium in the mouse model.
EDI048 demonstrated dose-dependent efficacy with a 0.3, 1.1 and 3.1 log reduction in oocyst shedding at 1, 3 and 10 mg kg−1 doses, respectively.
EDI048 is a soft drug in all tested preclinical species and had no human-specific metabolites, warranting further safety and efficacy profiling.
EDI048 blocks membrane biogenesis, preventing the formation of functional merozoites.
| M.Wt | 476.92 | |
| Formula | C25H21ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl 2-chloro-5-(N-methyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamido)benzoate |
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1. Manjunatha UH, et al. Nat Microbiol. 2024 Oct 8. doi: 10.1038/s41564-024-01810-x.
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