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UCT594

Chemical Structure : UCT594

CAS No.: 2044523-95-5

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UCT594 (UCT-594)

Catalog No.: PC-22969Not For Human Use, Lab Use Only.

UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.
    UCT594 inhibits P. falciparum asexual blood-stage activity.
    UCT594 is active against most stages of the parasite life cycle in vitro.
    UCT594 demonstrates concentration-dependent killing in the P. falciparum-infected NSG mouse model.

    Physicochemical Properties

    M.Wt 359.31
    Formula C18H12F3N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)benzoic acid

    References

    1. Gibhard L, et al. Antimicrob Agents Chemother. 2024 Aug 28:e0084224.

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