Chemical Structure : UCT594
Catalog No.: PC-22969Not For Human Use, Lab Use Only.
UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.
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UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog.
UCT594 inhibits P. falciparum asexual blood-stage activity.
UCT594 is active against most stages of the parasite life cycle in vitro.
UCT594 demonstrates concentration-dependent killing in the P. falciparum-infected NSG mouse model.
M.Wt | 359.31 | |
Formula | C18H12F3N3O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Gibhard L, et al. Antimicrob Agents Chemother. 2024 Aug 28:e0084224.
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