SW584 | Pf20Sβ5 inhibitor | Probechem Biochemicals

Chemical Structure : SW584

SW584 (SW 584, SW-584)

Catalog No.: PC-22800Not For Human Use, Lab Use Only.

SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2).

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Biological Activity

Physicochemical Properties

M.Wt	420.50
Formula	C20H25FN4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-(2-fluoroethoxy)acetyl)-N-((4-(6-methylpyridin-3-yl)thiazol-2-yl)methyl)piperidine-3-carboxamide

References

1. Aloysus Lawong, et al. Cell Chem Biol, July 30, 2024

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SW584 (SW 584, SW-584)

Biological Activity

Physicochemical Properties

References

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