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AZ-1

Chemical Structure : AZ-1

CAS No.: 803735-54-8

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AZ-1 (ABCA1/apoE inducer AZ-1)

Catalog No.: PC-63495Not For Human Use, Lab Use Only.

AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZ-1 is a small molecule inducer of ABCA1 and apoE that act through indirect activation of the LXR pathway, shows purinergic receptor P2X7 antagonist activity.
    AZ-1 upregulates ABCA1 across multiple CNS cell types, including human astrocytes, pericytes, and microglia, through an indirect LXR mechanism and that also independently inhibit P2X7 receptor activity.

    Physicochemical Properties

    M.Wt 430.977
    Formula C23H31ClN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(6-chloro-2-(3-((2-hydroxyethyl)amino)pyrrolidin-1-yl)quinolin-5-yl)-2-cyclohexylacetamide

    References

    1. Fan J, et al. J Lipid Res. 2018 May;59(5):830-842.

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