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AZ10606120 dihydrochloride

Chemical Structure : AZ10606120 dihydrochloride

CAS No.: 607378-18-7

AZ10606120 dihydrochloride (AZ 10606120;AZ-10606120)

Catalog No.: PC-63426Not For Human Use, Lab Use Only.

AZ10606120 is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ10606120 is a potent, specific P2X7 receptor antagonist with Kd of 1.4 and 19 nM at human and rat P2X7 receptors respectively; strongly inhibits tumor growth in B16-inoculated C57Bl/6 mice.

Physicochemical Properties

M.Wt 495.489
Formula C25H36Cl2N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

References

1. Yan Z, et al. J Neurosci. 2010 Oct 20;30(42):14213-24.

2. Mohammed A, et al. Oncotarget. 2017 Oct 26;8(58):97822-97834.

3. Adinolfi E, et al. Cancer Res. 2012 Jun 15;72(12):2957-69.

4. Michel AD, et al. Br J Pharmacol. 2008 Feb;153(4):737-50.

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