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Chemical Structure : AZ12441970
Catalog No.: PC-63386Not For Human Use, Lab Use Only.
AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8.
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AZ12441970 is a selective TLR7 agonist with pEC50 of 6.8 and 6.6 for human and rat TLR7, shows inactivity against TLR8.
AZ12441970 sufficiently activates the IFN pathway.
AZ12441970 shows efficacy in a mouse allergic airway model with minimal induction of systemic IFN-α.
| M.Wt | 527.67 | |
| Formula | C27H41N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Biffen M, et al. Br J Pharmacol. 2012 May;166(2):573-86.
2. Edwards S, et al. J Immunol. 2013 Mar 15;190(6):2585-92.
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