AZ13824374 | ATAD2 inhibitor | Probechem Biochemicals

Chemical Structure : AZ13824374

AZ13824374 (AZ 13824374)

Catalog No.: PC-72779Not For Human Use, Lab Use Only.

AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM.

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Biological Activity

AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM.
AZ13824374 shows cellular target engagement and antiproliferative activity in a range of breast cancer models.

Physicochemical Properties

M.Wt	562.694
Formula	C30H39FN8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one

References

1. Winter-Holt JJ, et al. J Med Chem. 2022 Feb 24;65(4):3306-3331.

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AZ13824374 (AZ 13824374)

Biological Activity

Physicochemical Properties

References

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