| Cat. No. |
Product Name |
Information |
| PC-23522 |
XY221
BRD4 BD2 inhibitor
|
XY221 is a potent, BRD4 BD2-selective inhibitor with IC50 of 5.8 nM, >600-fold selective over BRD4 BD1 and 9–32-fold over BRD2/3/T BD2. |
| PC-22395 |
Tafbromin
TAF1(2) inhibitor
|
Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation. |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21341 |
PFI-6
MLLT1/3 ligand
|
PFI-6 is a selective small-molecule chemical probe inhibitor for the YEATS domain of MLLT1 and MLLT3 with IC50 of 140 nM and 160 nM, respectively. |
| PC-21302 |
SGC-CBP30
CBP/p300 inhibitor
|
SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain inhibitor with Kd values of 21/32 nM, respectively. |
| PC-21166 |
GNE-235
PBRM1(2) inhibitor
|
GNE-235 (GNE235) is a potent, selective inhibitor of the second bromodomain of polybromo-1 (PBRM1; BAF180; PB1) with KD value of 0.28 uM in BROMOscan assays. |
| PC-21072 |
IV-255
BRG1 bromodomain inhibitor
|
IV-255 is a next-generation selective inhibitor of BRG1 bromodomain, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma. |
| PC-20838 |
BBC1115
BET inhibitor
|
BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins. |
| PC-20573 |
Birabresib
BET bromodomain inhibitor
|
Birabresib (OTX-015) is a potent, competitive inhibitor of BET bromodomain BRD2, BRD3, and BRD4 with EC50 of 10-19 nM, inhibits binding of BRD2, BRD3, and BRD4 to acetylated histone H4 (AcH4) with IC50 of 92-112 nM. |
| PC-20463 |
BI 1702135
SMARCA2 binder
|
BI 1702135 (Compound 4) is a potent SMARCA2 binder for targeted protein degradation (PROTAC) design as BI 1810284 (ACBI2, Cat. PC-20464). |
| PC-20343 |
FHT-2344
BRG1/BRM inhibitor
|
FHT-2344 (FHT2344) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 26 and 13 nM respectively, the ATPase component of the BAF complex. |
| PC-20342 |
FHT-1015
BRG1/BRM inhibitor
|
FHT-1015 (FHT1015) is a potent, selective inhibitor of SMARCA4 and SMARCA2 (BRG1 and BRM) with IC50 of 4 and 5 nM respectively, the ATPase component of the BAF complex. |
