| Cat. No. |
Product Name |
Information |
| PC-49210 |
GNE-064
BRG1/BRM inhibitor
|
GNE-064 (GNE064) is a potent, selective, and orally bioavailable inhibitor of the bromodomains of SMARCA2 (BRM), SMARCA4 (BRG1) and PBRM1 (polybromo-1) bromodomain 5 (PBRM1(5)) with IC50 of 10 nM, 16 nM and 18 nM, respectively. |
| PC-49152 |
EA-89-YM35
BRD9 inhibitor
|
BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way. |
| PC-49079 |
RVX-208
BET BD2 inhibitor
|
Apabetalone (RVX-208) is a potent, selective inhibitor of second BET bromodomains (BD2) with IC50 of 0.51 uM, 170-fold selectivity over BD1 (IC50=87 uM). |
| PC-38776 |
CDD-956
BET BD1 inhibitor
|
CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1 respectively, with high selectivity (>500-fold) over BET BD2 proteins. |
| PC-38775 |
CDD-787
BET BD1 inhibitor
|
CDD-787 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 3.3 nM for BRDT-BD1 and BRD4-BD1, respectively, with high selectivity (>3,000-fold) over BET BD2 proteins. |
| PC-38761 |
BRD8 inhibitor DN01
BRD8 inhibitor
|
BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300. |
| PC-38620 |
BI 894999
BRD4 inhibitor
|
BI 894999 is a novel potent, selective BET inhibitor with IC50 of 5 and 41 nM for BRD4-BD1 and BRD4-BD2 bromodomains, respectively. |
| PC-38413 |
FHT-1204
BRG1/BRM inhibitor
|
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50 of < 10 nM. |
| PC-73385 |
SRX3305
BTK/PI3K/BRD4 inhibitor
|
SRX3305 is a potent, triple BTK/PI3K/BRD4 inhibitor with IC50 of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ respectively, inhibits BRD4 BD1 and BD2 with IC50 of 77 and 95 nM. |
| PC-73384 |
SRX3262
BTK/PI3K/BRD4 inhibitor
|
SRX3262 (SRX 3262, SRX 3262) is a potent, triple action BTK, PI3K and BRD4 inhibitor with potency against BTK (IC50=35 nM), PI3Kδ (IC50=16 nM), PI3Kα (IC50=64 nM), and both bromodomains of BRD4 (IC50 BD1=228 nM, IC50 BD2=348 nM). |
| PC-73383 |
SRX3177
BRD4/PI3K/CDK4/6 inhibitor
|
SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM). |
| PC-73382 |
SRX3212
dual BRD4/PI3Kα inhibitor
|
SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα. |
