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Chemical Structure : SJ1461
Catalog No.: PC-20312Not For Human Use, Lab Use Only.
SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.
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SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.
SJ1461 displays high potency in the panel of acute leukaemia and medulloblastoma cell lines.
| M.Wt | 483.99 | |
| Formula | C21H18ClN7OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mladen Koravovic, et al. Eur J Med Chem. 2023 Mar 4;251:115246.
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