SJ1461 | BET inhibitor | Probechem Biochemicals

Chemical Structure : SJ1461

SJ1461 (SJ-1461)

Catalog No.: PC-20312Not For Human Use, Lab Use Only.

SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.

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Biological Activity

SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.
SJ1461 displays high potency in the panel of acute leukaemia and medulloblastoma cell lines.

Physicochemical Properties

M.Wt	483.99
Formula	C21H18ClN7OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(1,3,4-thiadiazol-2-yl)acetamide

References

1. Mladen Koravovic, et al. Eur J Med Chem. 2023 Mar 4;251:115246.

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SJ1461 (SJ-1461)

Biological Activity

Physicochemical Properties

References

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