| Cat. No. |
Product Name |
Information |
| PC-35848 |
TP-238
|
TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120nM for BPTF in ITC assays. |
| PC-35750 |
CN750
BRD4 inhibitor
|
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM. |
| PC-35749 |
CN427
BRD4 inhibitor
|
CN427 (CN-427) is a a novel potent BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM. |
| PC-35746 |
BRM014
BRG1/BRM inhibitor
|
BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both. |
| PC-35710 |
SGC-iMLLT
YEATS inhibitor
|
SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1). |
| PC-35709 |
GNE-371
TAF1(2) inhibitor
|
GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members. |
| PC-35692 |
BRD4 inhibitor Compound V
|
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively. |
| PC-35554 |
GSK4027
PCAF/GCN5 inhibitor
|
GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both. |
| PC-35423 |
MS645
BRD4 inhibitor
|
MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2. |
| PC-35401 |
BET inhibitor CF53
BET inhibitor
|
BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1). |
| PC-35400 |
QCA276
BET inhibitor
|
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570. |
| PC-35172 |
ABBV-744
BET BD2 inhibitor
|
ABBV-744 (ABBV744) is a highly potent and selective inhibitor of the BD2 domain of BET family proteins with IC50 of 4-18 nM for BD2 of BRD2, BRD3, BRD4 and BRDT. |
