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Cat. No. Product Name Information
PC-35749

CN427

BRD4 inhibitor

CN427 (CN-427) is a a novel potent BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM.
PC-35746

BRM014

BRG1/BRM inhibitor

BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.
PC-35710

SGC-iMLLT

YEATS inhibitor

SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1).
PC-35709

GNE-371

TAF1(2) inhibitor

GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members.
PC-35692

BRD4 inhibitor Compound V

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
PC-35554

GSK4027

PCAF/GCN5 inhibitor

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both.
PC-35423

MS645

BRD4 inhibitor

MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2.
PC-35401

BET inhibitor CF53

BET inhibitor

BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
PC-35400

QCA276

BET inhibitor

QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.
PC-35172

ABBV-744

BET BD2 inhibitor

ABBV-744 (ABBV744) is a highly potent and selective inhibitor of the BD2 domain of BET family proteins with IC50 of 4-18 nM for BD2 of BRD2, BRD3, BRD4 and BRDT.
PC-35097

ZL0454

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
PC-35096

ZL0420

BRD4 inhibitor

ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.

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