| Cat. No. |
Product Name |
Information |
| PC-35746 |
BRM014
BRG1/BRM inhibitor
|
BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both. |
| PC-35710 |
SGC-iMLLT
YEATS inhibitor
|
SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1). |
| PC-35709 |
GNE-371
TAF1(2) inhibitor
|
GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members. |
| PC-35692 |
BRD4 inhibitor Compound V
|
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively. |
| PC-35554 |
GSK4027
PCAF/GCN5 inhibitor
|
GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both. |
| PC-35423 |
MS645
BRD4 inhibitor
|
MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2. |
| PC-35401 |
BET inhibitor CF53
BET inhibitor
|
BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1). |
| PC-35400 |
QCA276
BET inhibitor
|
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570. |
| PC-35172 |
ABBV-744
BET BD2 inhibitor
|
ABBV-744 (ABBV744) is a highly potent and selective inhibitor of the BD2 domain of BET family proteins with IC50 of 4-18 nM for BD2 of BRD2, BRD3, BRD4 and BRDT. |
| PC-35097 |
ZL0454
|
ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively. |
| PC-35096 |
ZL0420
BRD4 inhibitor
|
ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively. |
| PC-35015 |
JQ1-Az
|
JQ1-Az is a JQ1 derivative for PROTAC synthesis. |
