| Cat. No. |
Product Name |
Information |
| PC-21726 |
DUAL946
BET/HDAC inhibitor
|
DUAL946 is a sub-micromolar inhibitor of both BET and class I & IIb HDAC proteins with IC50 of 0.05/0.25/0.42/14.13/34.89 uM for BRD4/HDAC1/HDAC2/HDAC5/HDAC7/HDAC9, respectively. |
| PC-21651 |
DW-71177
BET BD1 inhibitor
|
DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity. |
| PC-21331 |
LT052
BET BD1 inhibitor
|
LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2. |
| PC-21330 |
MS436
BRD4 BD1 inhibitor
|
MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2. |
| PC-21329 |
GSK023
BET BD1 inhibitor
|
GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2. |
| PC-21303 |
CN210
BET bromodomain inhibitor
|
CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay. |
| PC-21267 |
Dual PI3K/BET 18DS
PI3K/BET inhibitor
|
Dual PI3K/BET 18DS is a potent, chimeric dual PI3K/BET bromodomain inhibitor, demonstrates high selectivity, nanomolar range cellular potency, and compelling in vivo efficacy. |
| PC-21167 |
GNE-234
|
GNE-234 is the negative control compound of the selective PBRM1(2) inhibitor GNE-235. |
| PC-21166 |
GNE-235
PBRM1(2) inhibitor
|
GNE-235 (GNE235) is a potent, selective inhibitor of the second bromodomain of polybromo-1 (PBRM1; BAF180; PB1) with KD value of 0.28 uM in BROMOscan assays. |
| PC-21073 |
IV-275
BRG1/BRM inhibitor
|
IV-275 is a next-generation inhibitor of BRG1 and BRM bromodomains, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma. |
| PC-20948 |
DDO-8926
BET inhibitor
|
DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2). |
| PC-72758 |
BPTF inhibitor BZ1
BPTF inhibitor
|
BPTF inhibitor BZ1 is a potent, selective, cell-active inhibitor of bromodomain PHD finger transcription factor (BPTF) with Kd of 6.3 nM, >350-fold selectivity over BET bromodomains. |
