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I-BET726

Chemical Structure : I-BET726

CAS No.: 1300031-52-0

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I-BET726 (GSK1324726A;GSK 1324726A;GSK-1324726A;I-BET 726)

Catalog No.: PC-43808Not For Human Use, Lab Use Only.

I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively.
I-BET726 (GSK1324726A) exhibits growth inhibition with a median growth IC50 value of 75 nM in neuroblastoma cell lines.
I-BET726 (GSK1324726A) oral administration to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression.

Physicochemical Properties

M.Wt 434.9147
Formula C25H23ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-

References

1. Gosmini R, et al. J Med Chem. 2014 Oct 9;57(19):8111-31.

2. Wyce A, et al. PLoS One. 2013 Aug 23;8(8):e72967.

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