| Cat. No. |
Product Name |
Information |
| PC-62283 |
BAY1238097
BET inhibitor
|
BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay. |
| PC-62282 |
CPI-0610
BET inhibitor
|
Pelabresib (CPI-0610) is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay. |
| PC-62281 |
INCB054329
BET inhibitor
|
INCB 054329 (INCB054329) is a potent, selective, pan-BET bromodomain inhibitor with biochemical IC50 of 1-119 nM against BRD2, BRD3, and BRD4 and BRDT. |
| PC-62279 |
PFI-3
BRG/PB1 inhibitor
|
PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM. |
| PC-62278 |
BRD-IN-17
Family VIII bromodomain inhibitor
|
BRD-IN-17 is a cell permeable, family VIII bromodomain tool compound with additional PB1(2) activity over and above that of PFI-3. |
| PC-62277 |
BRD-IN-26
PB1(5) inhibitor
|
BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 (PB1(5)) with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively. |
| PC-62276 |
OF-1
|
OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM. |
| PC-62274 |
RVX2135
BET inhibitor
|
RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively. |
| PC-62273 |
TP-472
BRD9/BRD7 inhibitor
|
TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay). |
| PC-62272 |
BI 7271
BRD9/BRD7 inhibitor
|
BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9. |
| PC-62271 |
BI 7189
BRD9 inhibitor
|
BI 7189 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9, displays >1,000 fold selectivity over the bromodomains of BRD4. |
| PC-62270 |
BMS 986158
BET inhibitor
|
BMS-986158 (BMS986158) is a potent and selective BET inhibitor, disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. |
