| Cat. No. |
Product Name |
Information |
| PC-62281 |
INCB054329
BET inhibitor
|
INCB 054329 (INCB054329) is a potent, selective, pan-BET bromodomain inhibitor with biochemical IC50 of 1-119 nM against BRD2, BRD3, and BRD4 and BRDT. |
| PC-62279 |
PFI-3
BRG/PB1 inhibitor
|
PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM. |
| PC-62278 |
BRD-IN-17
Family VIII bromodomain inhibitor
|
BRD-IN-17 is a cell permeable, family VIII bromodomain tool compound with additional PB1(2) activity over and above that of PFI-3. |
| PC-62277 |
BRD-IN-26
PB1(5) inhibitor
|
BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 (PB1(5)) with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively. |
| PC-62276 |
OF-1
|
OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM. |
| PC-62274 |
RVX2135
BET inhibitor
|
RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively. |
| PC-62273 |
TP-472
BRD9/BRD7 inhibitor
|
TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay). |
| PC-62272 |
BI 7271
BRD9/BRD7 inhibitor
|
BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9. |
| PC-62271 |
BI 7189
BRD9 inhibitor
|
BI 7189 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9, displays >1,000 fold selectivity over the bromodomains of BRD4. |
| PC-62270 |
BMS 986158
BET inhibitor
|
BMS-986158 (BMS986158) is a potent and selective BET inhibitor, disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth. |
| PC-62269 |
BAZ2-ICR
|
BAZ2-ICR is a potent, selective and cell-active inhibitor of BAZ2A (Kd=109 nM, IC50=130 nM) and BAZ2B (Kd=170 nM, IC50=180 nM) bromodomains. |
| PC-62224 |
biBET
BET inhibitor
|
biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively. |
