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Chemical Structure : BAY1238097
CAS No.: 1564268-08-1
Catalog No.: PC-62283Not For Human Use, Lab Use Only.
BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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BAY1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay.
BAY1238097 shows selectivity of the compound for BRD4.
BAY1238097 strongly reduces c-Myc transcript and protein levels in MOLM-13 (AML) and MOLP-8 (MM) cell lines.
BAY1238097 exhibits strong efficacy in the AML models THP-1, MOLM-13 and KG-1.
| M.Wt | 451.571 | |
| Formula | C25H33N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-7,8-dimethoxy-N,4-dimethyl-1-(4-(4-methylpiperazin-1-yl)phenyl)-4,5-dihydro-3H-benzo[d][1,2]diazepine-3-carboxamide |
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1. Bernasconi E, et al. Br J Haematol. 2017 Jun 27. doi: 10.1111/bjh.14803.
2. Patent WO2014026997A1.
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