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BRPF1B TRIM24-IN-34

Chemical Structure : BRPF1B TRIM24-IN-34

CAS No.: 1242907-48-7

BRPF1B TRIM24-IN-34

Catalog No.: PC-62285Not For Human Use, Lab Use Only.

BRPF1B TRIM24-IN-34 is a selective BRPF1B/TRIM24 dual inhibitor that binds with KD of 137 and 222 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRPF1B TRIM24-IN-34 is a selective BRPF1B/TRIM24 dual inhibitor that binds with KD of 137 and 222 nM, respectively.
    BRPF1B TRIM24-IN-34 exhibits good selectivity over other bromodomains.
    BRPF1B TRIM24-IN-34 showes no significant cytotoxicity in a panel of cancer cell lines (GI50>10 uM).

    Physicochemical Properties

    M.Wt 499.538
    Formula C24H25N3O7S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide

    References

    1. Bennett J, et al. J Med Chem. 2016 Feb 25;59(4):1642-7.

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