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Request The Product List ofBromodomain Bromodomain

Cat. No. Product Name Information
PC-63216

IACS-9571

TRIM24 inhibitor

IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
PC-43027

BET-BAY 002

BET inhibitor

BET-BAY 002 is a potent BET bromodomain inhibitor, shows efficacy in a multiple myeloma model.
PC-43338

JQ1

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.
PC-62986

AZD5153

BET inhibitor

AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
PC-62938

BRD9-IN-28

BRD9/BRD7 inhibitor

BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9.
PC-62845

GNE-375

BRD9 inhibitor

GNE-375 (GNE375) is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1.
PC-62636

FL-411

BRD4 inhibitor

FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells.
PC-62550

GNE-886

CECR2 inhibitor

GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM.
PC-62511

CPI203

BET inhibitor

CPI 203 (TEN 010, JQ-2, RG-6146, RO6870810) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM.
PC-62510

BET BRD4 inhibitor Compound II-25

BRD4 BD1 inhibitor

BET BRD4 inhibitor Compound II-25 is a potent BRD4-BD1 inhibitor with IC50 of 8 nM.
PC-62475

Olinone

BET BRD1 inhibitor

Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM).
PC-62474

MS417

BRD4 inhibitor

MS417 (GTPL-7512) is a highly specific BET bromodomain inhibitor that binds to BRD4-BD1 and BRD4 BD2 with Kd of 36.1 uM and 25.4 uM respectively.

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