| Cat. No. |
Product Name |
Information |
| PC-43027 |
BET-BAY 002
BET inhibitor
|
BET-BAY 002 is a potent BET bromodomain inhibitor, shows efficacy in a multiple myeloma model. |
| PC-43338 |
JQ1
|
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively. |
| PC-62986 |
AZD5153
BET inhibitor
|
AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM. |
| PC-62938 |
BRD9-IN-28
BRD9/BRD7 inhibitor
|
BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9. |
| PC-62845 |
GNE-375
BRD9 inhibitor
|
GNE-375 (GNE375) is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1. |
| PC-62636 |
FL-411
BRD4 inhibitor
|
FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells. |
| PC-62550 |
GNE-886
CECR2 inhibitor
|
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM. |
| PC-62511 |
CPI203
BET inhibitor
|
CPI 203 (TEN 010, JQ-2, RG-6146, RO6870810) is a primary amide analog of (+)-JQ1and a BET bromodomain inhibitor that shows cytotoxicity against MCL cell lines with GI50 of 0.1-0.3 uM. |
| PC-62510 |
BET BRD4 inhibitor Compound II-25
BRD4 BD1 inhibitor
|
BET BRD4 inhibitor Compound II-25 is a potent BRD4-BD1 inhibitor with IC50 of 8 nM. |
| PC-62475 |
Olinone
BET BRD1 inhibitor
|
Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM). |
| PC-62474 |
MS417
BRD4 inhibitor
|
MS417 (GTPL-7512) is a highly specific BET bromodomain inhibitor that binds to BRD4-BD1 and BRD4 BD2 with Kd of 36.1 uM and 25.4 uM respectively. |
| PC-62389 |
GSK1379725A
BPTF inhibitor
|
GSK1379725A is the first selective small molecule inhibitor of BPTF bromodomain (bromodomain PHD finger transcription factor) with Kd of 2.8 uM in a cell-based reporter assay, shows no binding activity for Brd4. |
