| Cat. No. |
Product Name |
Information |
| PC-20160 |
CG13250
BET inhibitor
|
CG13250 (CG 13250, CG250) is a potent, selective and orally bioavailable BET bromodomain inhibitor with Kd of 44 nM (BRD4), IC50 of 1.1 uM (BRD4 BD1+BD2). |
| PC-20123 |
BI-4827
|
BI-4827 (BI 4827) is the negative control compound of BI-7190, which is a potent, selective chemical probe targeting the bromodomain of BPTF. |
| PC-20122 |
BI-7190
BPTF inhibitor
|
BI-7190 (BI 7190) is a potent, selective chemical probe targeting the bromodomain of BPTF with binding Kd of 3.5 nM. |
| PC-20119 |
BRM012
BRM/BRG1 inhibitor
|
BRM012 (SMARCA2/SMARCA4 inhibitor 12) is a potent inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1/SMARCA4) with IC50 of <5 nM for both. |
| PC-49860 |
FT-6876
CBP/p300 inhibitor
|
FT-6876 (FT 6876) is a potent, selective, orally active CBP/p300 bromodomains inhibitor with IC50 of 5/2 nM, respectively, >500-fold selectivity over BRD4 (IC50=2,320 nM) and other bromodomains. |
| PC-49600 |
YEATS4 binder 4d
YEATS4 inhibitor
|
YEATS4 binder 4d is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 33 nM, >10-fold selectivity over YEATS1, 2 and 3. |
| PC-49599 |
YEATS4 binder 4e
YEATS4 inhibitor
|
YEATS4 binder 4e is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 37 nM, >15-fold selectivity over YEATS1, 2 and 3. |
| PC-49526 |
BAZ1A inhibitor Cpd2
BAZ1A inhibitor
|
BAZ1A inhibitor Cpd2 is a small molecule BAZ1A bromodomain inhibitor with KD value of 0.52 uM, displays good anti-viability activity against cancer cell lines expressing a high level of BAZ1A. |
| PC-49467 |
I-BET432
Pan-BET inhibitor
|
I-BET432 is a potent, highly ligand-efficient, orally active pan-BET bromodomain inhibitor with pIC50 of 7.5/7.2 for BRD4 BD1 and BD2 respectively. |
| PC-49366 |
iBRD4-BD1
BRD4-BD1 inhibitor
|
iBRD4-BD1 is a potent, selective inhibitor of the first BRD4 bromodomain with IC50 of 12 nM, shows 23- to 6200-fold intra-BET selectivity. |
| PC-49300 |
TDI-11055
ENL YEATS inhibitor
|
TDI-11055 (TDI 11055) is a potent, selective and orally bioavailable inhibitor of the acyl-lysine reader ENL/AF9 YEATS domain with IC50 of 0.05 and 0.07 uM, respectively. |
| PC-49278 |
GSK761
SP140 inhibitor
|
GSK761 (GSK-761) is the first small molecule inhibitor of bromodomain-containing protein SP140, inhibits macrophage inflammatory function. |
