| Cat. No. |
Product Name |
Information |
| PC-73383 |
SRX3177
BRD4/PI3K/CDK4/6 inhibitor
|
SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM). |
| PC-73382 |
SRX3212
dual BRD4/PI3Kα inhibitor
|
SRX3212 (SRX 3212) is a potent, dual BRD4/PI3Kα inhibitor with IC50 of 3.7 nM (BRD4 BD1) and 32 nM (BRD4 BD2), IC50 of 22 nM for PI3Kα. |
| PC-73226 |
SMARCA-PB1 inhibitor 22
BRM/BRG1 inhibitor
|
SMARCA-PB1 inhibitor 22 is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively. |
| PC-73224 |
XY153
BET BD2 inhibitor
|
XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1. |
| PC-73089 |
iP300w
p300/CBP inhibitor
|
iP300w is a potent p300/CBP inhibitor, inhibits p300-mediated H3K9 acetylation with IC50 of 33 nM in HTRF assay. |
| PC-73041 |
ZL0580
BRD4 inhibitor
|
ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation. |
| PC-72866 |
CRCM5484
BET-BD2 inhibitor
|
CRCM5484 is a potent, BET BDII-selective inhibitor with IC50 of 130/20/71 nM for BRD4-BD2/BRD3-BD2/BRD2-BD2, respectively. |
| PC-72821 |
XP-524
BET/EP300 inhibitor
|
XP-524 (XL-223, XP524) is a potent, dual-BET/EP300 inhibitor, inhibits BRD4-BD (IC50=5.8 nM) and BRD4-BD2 (IC50=1.5 nM), binds strongly to and inhibits EP300 and CBP proteins with IC50 of 28 and 116 nM, respectively. |
| PC-72789 |
NVS-BPTF-1
BPTF bromodomain inhibitor
|
NVS-BPTF-1 is the first highly potent and selective BPTF-bromodomain inhibitor with IC50 of 56 nM in an AlphaScreen assay and Kd of 71 nM in a BLI assay. |
| PC-72706 |
LM146
PB1 bromodomain inhibitor
|
LM146 (LM-146) is a potent and selective inhibitor of pan-PB1 bromodomains (Polybromo-1 protein, PBRM1 or BAF180), binds to PB1(2), PB1(5), and SMARCA2B with KD values of 110, 61, and 2100 nM, respectively. |
| PC-72676 |
UM-002
BRD4 inhibitor
|
UM-002 is a highly potent, selective, brain penetrant BRD4 bromodomain inhibitor with IC50 of 8.8 and 2.4 nM for BRD4-1 and BRD4-2, respectively. |
| PC-72646 |
I-BET567
pan-BET inhibitor
|
I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT. |
