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BBC1115

Chemical Structure : BBC1115

CAS No.:

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BBC1115 (BBC 1115)

Catalog No.: PC-20838Not For Human Use, Lab Use Only.

BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.
BBC1115 is structurally distinct from known BET inhibitors.
BBC1115 treatment resulted in a typical response to BET inhibitors, represented by suppression of MYC programs and dissociation of BRD4 from chromatin.
BBC1115 suppresses BET-dependent gene expression programs and exhibits anti-proliferative activity in vitro and in vivo.

Physicochemical Properties

M.Wt 539.60
Formula C28H27F2N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CC2=C(OC)C=CC(C(C=C3)=CN(C)C3=O)=C2S1)N(CC4=CC=C(C(F)F)C=C4)CCC(NC)=O

References

1. Seoyeon Jeong, et al. Mol Ther Nucleic Acids. 2023 Apr 24;32:637-649.

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