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BBC1115

Chemical Structure : BBC1115

CAS No.: 2995398-68-8

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BBC1115 (BBC 1115)

Catalog No.: PC-20838Not For Human Use, Lab Use Only.

BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.
    BBC1115 is structurally distinct from known BET inhibitors.
    BBC1115 treatment resulted in a typical response to BET inhibitors, represented by suppression of MYC programs and dissociation of BRD4 from chromatin.
    BBC1115 suppresses BET-dependent gene expression programs and exhibits anti-proliferative activity in vitro and in vivo.

    Physicochemical Properties

    M.Wt 539.60
    Formula C28H27F2N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(difluoromethyl)benzyl)-4-methoxy-7-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-N-(3-(methylamino)-3-oxopropyl)benzo[b]thiophene-2-carboxamide

    References

    1. Seoyeon Jeong, et al. Mol Ther Nucleic Acids. 2023 Apr 24;32:637-649.

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