| Cat. No. |
Product Name |
Information |
| PC-26562 |
BRD4 degrader ZZ1
BRD4 BD1 degrader
|
BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1. |
| PC-26535 |
16D10
TSLP production inhibitor, BRD4 ligand
|
16D10 is a small molecule inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 1.5 uM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region. |
| PC-26533 |
TK-285
TSLP production inhibitor, BRD4 ligand
|
TK-285 is a potent inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 190 nM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region. |
| PC-26515 |
MDP5
BRD4/PI3K inhibitor
|
MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2. |
| PC-26244 |
GSK785
BRD2/4 inhibitor
|
GSK785 (GSK-785) is a BRD2/4-selective bivalent BET I nhibitor with pIC50 of 7.9 and 8.5 in PPI assays against the CRDA parameters, shows pIC50 of 7.4 in the hWB MCP1 assay, 125-fold selectivity for BRD2 over BRD3, 13-fold selectivity for BRD2 over BRD4, and 10-fold selectivity for BRD4 over BRD3. |
| PC-25946 |
CZL-077
p300/CBP inhibitor
|
CZL-077 is a potent, selective and orally active p300/CBP bromodomain inhibitor with IC50 of 34 nM and 52 nM respectively, selective over BRD4 BD1 and BD2. |
| PC-25803 |
PBRM1-BD2 inhibitor 34
PBRM1-BD2 inhibitor
|
PBRM1-BD2 inhibitor 34 (PBRM1-BD2-IN-8) is a potent, selective PBRM1 bromodomain inhibitor with Kd of4.4 uM, IC50 of 0.16 uM for PBRM1-BD2, shows promising inhibition toward PBRM1-dependent prostate cancer cell line LNCaP with IC50 of 9 uM. |
| PC-25802 |
PBRM1 inhibitor PB16
PBRM1-BD2 inhibitor
|
PBRM1 inhibitor PB16 is a selective, cell-active Polybromo-1 (PBRM1) bromodomain inhibitor with ITC KD of 2 uM for PBRM1-BD2, and IC50 of 0.26 uM in AlphaScreen assays. |
| PC-25799 |
DLG-41
GAS41 YEATS domain inhibitor
|
DLG-41 is a potent, selective inhibitor of GAS41 YEATS domain with IC50 of 610 nM in in AlphaLISA assays, binds to GAS41 YEATS domain with ITC KD of 1.0 uM. |
| PC-24390 |
Y08197
CBP/EP300 inhibitor
|
Y08197 is a selective inhibitor of CBP/EP300 bromodomain, inhibits the CBP bromodomain with IC50 of 100.67 nM, high selectivity for CBP/EP300 over other bromodomain-containing proteins. |
| PC-24237 |
KB-0118
BET bromodomain
|
KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD). |
| PC-23888 |
LC-CE-7
CECR2 inhibitor
|
LC-CE-7 is a potent, sepecific and allosteric covalent CECR2 inhibitor with IC50 of 462 nM and Ki of 32.5 nM, exhibits covalent binding to Cys494 and allosteric regulation of the Kac pocket. |
