| Cat. No. |
Product Name |
Information |
| PC-27182 |
BRGi-39
BRG1 inhibitor
|
BRGi-39 (Z448047898) is a selective inhibitor of switch/sucrose non-fermentable (SWI/SNF) complex core ATPase subunit BRG1, blocks BRG1-BRD with exceptional selectivity and high affinity. |
| PC-27090 |
DUX4 inhibitor C06
DUX4 inhibitor
|
DUX4 inhibitor C06 is a potent, specific repressor of DUX4 and DUX4 target gene expression, exhibits binding to BAZ1A in vitro, also inhibits multiple kinases, including p38α, an upstream activator of DUX4. |
| PC-26818 |
LS-170
YEATS2 inhibitor
|
LS-170 is a potent, specific inhibitor of ATAC (Ada-two-A-containing) HAT complex subunit YEATS2 with IC50 of 0.14 uM (YEATS2 YEATS domain), shows no inhibitory effect for other YEATS domain family members, AF9, ENL and GAS41. |
| PC-26728 |
UMB298
CBP/P300 inhibitor
|
UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4. |
| PC-26723 |
FRC-303
CHD1 inhibitor
|
FRC-303 (CHD1 inhibitor 2s) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.14 uM. |
| PC-26722 |
FRC-222
CHD1 inhibitor
|
FRC-222 (CHD1 inhibitor 2n) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.15 uM. |
| PC-26563 |
BRD4 degrader ZZ2
BRD4 BD1 degrader
|
BRD4 degrader ZZ2 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 169 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1. |
| PC-26562 |
BRD4 degrader ZZ1
BRD4 BD1 degrader
|
BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1. |
| PC-26535 |
16D10
TSLP production inhibitor, BRD4 ligand
|
16D10 is a small molecule inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 1.5 uM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region. |
| PC-26533 |
TK-285
TSLP production inhibitor, BRD4 ligand
|
TK-285 is a potent inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 190 nM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region. |
| PC-26515 |
MDP5
BRD4/PI3K inhibitor
|
MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2. |
| PC-26244 |
GSK785
BRD2/4 inhibitor
|
GSK785 (GSK-785) is a BRD2/4-selective bivalent BET I nhibitor with pIC50 of 7.9 and 8.5 in PPI assays against the CRDA parameters, shows pIC50 of 7.4 in the hWB MCP1 assay, 125-fold selectivity for BRD2 over BRD3, 13-fold selectivity for BRD2 over BRD4, and 10-fold selectivity for BRD4 over BRD3. |
