| Cat. No. |
Product Name |
Information |
| PC-21732 |
XL-126
BET BD1 inhibitor
|
XL-126 (XL126) is a potent BD1-selective BET inhibitor with SPR binding KD value of 8.9 nM, has 185-fold BD1/BD2 selectivity. |
| PC-21726 |
DUAL946
BET/HDAC inhibitor
|
DUAL946 is a sub-micromolar inhibitor of both BET and class I & IIb HDAC proteins with IC50 of 0.05/0.25/0.42/14.13/34.89 uM for BRD4/HDAC1/HDAC2/HDAC5/HDAC7/HDAC9, respectively. |
| PC-21651 |
DW-71177
BET BD1 inhibitor
|
DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity. |
| PC-21331 |
LT052
BET BD1 inhibitor
|
LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2. |
| PC-21330 |
MS436
BRD4 BD1 inhibitor
|
MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2. |
| PC-21329 |
GSK023
BET BD1 inhibitor
|
GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2. |
| PC-21303 |
CN210
BET bromodomain inhibitor
|
CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay. |
| PC-21302 |
SGC-CBP30
CBP/p300 inhibitor
|
SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain inhibitor with Kd values of 21/32 nM, respectively. |
| PC-21267 |
Dual PI3K/BET 18DS
PI3K/BET inhibitor
|
Dual PI3K/BET 18DS is a potent, chimeric dual PI3K/BET bromodomain inhibitor, demonstrates high selectivity, nanomolar range cellular potency, and compelling in vivo efficacy. |
| PC-21167 |
GNE-234
|
GNE-234 is the negative control compound of the selective PBRM1(2) inhibitor GNE-235. |
| PC-21166 |
GNE-235
PBRM1(2) inhibitor
|
GNE-235 (GNE235) is a potent, selective inhibitor of the second bromodomain of polybromo-1 (PBRM1; BAF180; PB1) with KD value of 0.28 uM in BROMOscan assays. |
| PC-21073 |
IV-275
BRG1/BRM inhibitor
|
IV-275 is a next-generation inhibitor of BRG1 and BRM bromodomains, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma. |
