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Cat. No. Product Name Information
PC-21929

IACS-9571 hydrochloride

TRIM24 inhibitor

IACS-9571 hydrochloride is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
PC-21739

ZL0590

BRD4 BD1 inhibitor

ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1.
PC-21732

XL-126

BET BD1 inhibitor

XL-126 (XL126) is a potent BD1-selective BET inhibitor with SPR binding KD value of 8.9 nM, has 185-fold BD1/BD2 selectivity.
PC-21726

DUAL946

BET/HDAC inhibitor

DUAL946 is a sub-micromolar inhibitor of both BET and class I & IIb HDAC proteins with IC50 of 0.05/0.25/0.42/14.13/34.89 uM for BRD4/HDAC1/HDAC2/HDAC5/HDAC7/HDAC9, respectively.
PC-21651

DW-71177

BET BD1 inhibitor

DW-71177 (DW71177) is a potent and BD1-selective BET inhibitor with ITC KD of 6.7 nM (BRD4-BD1), 20-fold selective over BRD4-BD2, exhibits strong antileukemic activity.
PC-21331

LT052

BET BD1 inhibitor

LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.
PC-21330

MS436

BRD4 BD1 inhibitor

MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2.
PC-21329

GSK023

BET BD1 inhibitor

GSK023 is a potent, selective BET BD1 domain inhibitor with pIC50 of 7.8 against BRD4 BD1, >100-fold selective over BD2.
PC-21303

CN210

BET bromodomain inhibitor

CN210 is a quinazoline-based BET family inhibitor with Kd value of 70 nM for BRD4 (BD1,2) and IC50 of 0.94 uM in MV4-11 viability assay.
PC-21302

SGC-CBP30

CBP/p300 inhibitor

SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain inhibitor with Kd values of 21/32 nM, respectively.
PC-21267

Dual PI3K/BET 18DS

PI3K/BET inhibitor

Dual PI3K/BET 18DS is a potent, chimeric dual PI3K/BET bromodomain inhibitor, demonstrates high selectivity, nanomolar range cellular potency, and compelling in vivo efficacy.
PC-21167

GNE-234

GNE-234 is the negative control compound of the selective PBRM1(2) inhibitor GNE-235.

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