| Cat. No. |
Product Name |
Information |
| PC-61977 |
ZEN-3694
BET inhibitor
|
ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range. |
| PC-61863 |
RVX-297
|
RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively. |
| PC-61740 |
FT-001
BET inhibitor
|
FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1. |
| PC-61641 |
GNE-049
CBP/p300 inhibitor
|
GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively. |
| PC-50010 |
PLX51107
BET inhibitor
|
PLX51107 (OPN-51107, OPN5) is a novel structurally distinct BET bromodomain inhibitor that inhibits all four BET family proteins BRD2, BRD3, BRD4, and BRDT with low nanomolar potency. |
| PC-61330 |
Hexamethylene bisacetamide
BD2 inhibitor
|
Hexamethylene bisacetamide (HMBA, NSC 95580) is a cell differentiation inducer that inhibits activation of NF-κB function, Akt and ERK/MAPK cascade. |
| PC-70284 |
MS402
BRD4 BD1 inhibitor
|
MS402 (MS 402) is a potent, selective inhibitor of the first bromodomain of BET (BRD4-BD1) with Ki of 77 nM. |
| PC-61157 |
L-Moses
PCAF/KAT2B inhibitor
|
L-Moses (PCAF BRD inhibitor L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4. |
| PC-61151 |
XDM-CBP
CBP/p300 inhibitor
|
XDM-CBP is a highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family. |
| PC-61129 |
CD161
BET inhibitor
|
CD161 (NKR-P1A) is a potent, selective, orally bioavailable BET bromodomain inhibitor with IC50 of 7.2 and 28.2 nM for BRD4 BD2 and BRD4 BD1, respectively. |
| PC-61007 |
NI-42
BRPF1 inhibitor
|
BRPF1 inhibitor NI-42 (NI-42) is a potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM, with excellent selectivity over nonclass IV BRDs. |
| PC-60935 |
RX-37
BET inhibitor
|
RX-37 (RX37) is a potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4. |
