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Chemical Structure : RVX-297
CAS No.: 1044871-04-6
Catalog No.: PC-61863Not For Human Use, Lab Use Only.
RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 100 mg | $858 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively.
RVX-297 displays about 50-fold selectivity over BD1.
RVX-297 suppresses inflammatory gene expression in multiple immune cell types in culture.
RVX-297 reduces pro-inflammatory mediators assessed in splenic gene expression and serum proteins in LPS model of inflammation.
| M.Wt | 423.513 | |
| Formula | C24H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one |
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1. Kharenko OA, et al. Biochem Biophys Res Commun. 2016 Aug 12;477(1):62-7.
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