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Chemical Structure : RVX2135
Catalog No.: PC-62274Not For Human Use, Lab Use Only.
RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively.
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RVX2135 (RVX-2135) is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively.
RVX2135 blocks proliferation of Myc-induced mouse lymphoma cells and induces Caspase-dependent apoptosis.
RVX2135 exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks.
| M.Wt | 411.502 | |
| Formula | C23H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
2. Bhadury J, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.
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