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RVX2135

Chemical Structure : RVX2135

CAS No.: 1253733-17-3

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RVX2135 (RVX 2135, RVX-2135)

Catalog No.: PC-62274Not For Human Use, Lab Use Only.

RVX2135 is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RVX2135 (RVX-2135) is a novel potent and orally bioavailable inhibitor of Brd2, Brd3, Brd4, and BrdT with IC50 of 1.31, 0.58, 0.44, and 1.58 uM, respectively.
    RVX2135 blocks proliferation of Myc-induced mouse lymphoma cells and induces Caspase-dependent apoptosis.
    RVX2135 exhibits broad transcriptional effects in Myc-transgenic lymphoma cells affecting many transcription factor networks.

    Physicochemical Properties

    M.Wt 411.502
    Formula C23H29N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(2-(isopropylamino)ethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

    References

    1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

    2. Bhadury J, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.

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