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Chemical Structure : ZEN-3694
CAS No.: 1643947-30-1
Catalog No.: PC-61977Not For Human Use, Lab Use Only.
ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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ZEN-3694 is a novel potent, orally bioavailable BET bromodomain inhibitor, selectively binds to both bromodomains of the BET proteins, inhibiting the interaction of acetylated histone peptide with IC50 values in low nM range.
ZEN-3694 inhibits proliferation of MV4-11 AML cells with an IC50 of 0.2 uM, and inhibits MYC mRNA expression with an IC50 of 0.16 uM.
ZEN-3694 inhibits proliferation synergistically with the AR antagonists enzalutamide and ARN-509 in the AR positive VCAP prostate cancer cell line.
| M.Wt | 333.40 | |
| Formula | C19H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Imidazo[4,5-b]pyridin-2-amine, 6-(3,5-dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)- |
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1. Aggarwal RR, et al. Clin Cancer Res. 2020 Oct 15;26(20):5338-5347.
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