| Cat. No. |
Product Name |
Information |
| PC-26533 |
TK-285
TSLP production inhibitor, BRD4 ligand
|
TK-285 is a potent inhibitor of TSLP production, binds to the BD1 domain of BRD4 with Kd of 190 nM, inhibits TSLP production by preventing BRD4 from binding to the TSLP promoter region. |
| PC-26515 |
MDP5
BRD4/PI3K inhibitor
|
MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2. |
| PC-26244 |
GSK785
BRD2/4 inhibitor
|
GSK785 (GSK-785) is a BRD2/4-selective bivalent BET I nhibitor with pIC50 of 7.9 and 8.5 in PPI assays against the CRDA parameters, shows pIC50 of 7.4 in the hWB MCP1 assay, 125-fold selectivity for BRD2 over BRD3, 13-fold selectivity for BRD2 over BRD4, and 10-fold selectivity for BRD4 over BRD3. |
| PC-25946 |
CZL-077
p300/CBP inhibitor
|
CZL-077 is a potent, selective and orally active p300/CBP bromodomain inhibitor with IC50 of 34 nM and 52 nM respectively, selective over BRD4 BD1 and BD2. |
| PC-25803 |
PBRM1-BD2 inhibitor 34
PBRM1-BD2 inhibitor
|
PBRM1-BD2 inhibitor 34 (PBRM1-BD2-IN-8) is a potent, selective PBRM1 bromodomain inhibitor with Kd of4.4 uM, IC50 of 0.16 uM for PBRM1-BD2, shows promising inhibition toward PBRM1-dependent prostate cancer cell line LNCaP with IC50 of 9 uM. |
| PC-25802 |
PBRM1 inhibitor PB16
PBRM1-BD2 inhibitor
|
PBRM1 inhibitor PB16 is a selective, cell-active Polybromo-1 (PBRM1) bromodomain inhibitor with ITC KD of 2 uM for PBRM1-BD2, and IC50 of 0.26 uM in AlphaScreen assays. |
| PC-24390 |
Y08197
CBP/EP300 inhibitor
|
Y08197 is a selective inhibitor of CBP/EP300 bromodomain, inhibits the CBP bromodomain with IC50 of 100.67 nM, high selectivity for CBP/EP300 over other bromodomain-containing proteins. |
| PC-24237 |
KB-0118
BET bromodomain
|
KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD). |
| PC-23888 |
LC-CE-7
CECR2 inhibitor
|
LC-CE-7 is a potent, sepecific and allosteric covalent CECR2 inhibitor with IC50 of 462 nM and Ki of 32.5 nM, exhibits covalent binding to Cys494 and allosteric regulation of the Kac pocket. |
| PC-23763 |
IEM930
GAS41/YEATS4 inhibitor
|
IEM930 is a small molecule inhibitor targeting the GAS41 YEATS domain (YEATS4)) with ITC binding Kd of 32.6 uM, inhibits GAS41/ITGA4-mediated PI3K/Akt/mTOR signaling pathway in glioma cells. |
| PC-23754 |
CZL-046
p300 bromodomain inhibitor
|
CZL-046 is a potent, selective, and orally active p300 bromodomain inhibitor with IC50 of 3.3 nM, exhibits antiproliferative activity in the multiple myeloma (MM) cell line (OPM-2, IC50=51.5 nM). |
| PC-22992 |
Y06014
BET inhibitor
|
Y06014 is a selective BRD4(1) inhibitor with IC50 of 4.87 uM. |
