BRD4 degrader ZZ1

Chemical Structure : BRD4 degrader ZZ1

Catalog No.: PC-26562Not For Human Use, Lab Use Only.

BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1.

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Biological Activity

BRD4 degrader ZZ1 is CTLH-dependent BRD4 BD1 molecular glue degrader with DC50 of 502 nM in Jurkat cells, bridges YPEL5 and BRD4 BD1.
ZZ1 binds the ligand-binding pocket in YPEL5 that corresponds to CRBN CTD.
ZZ1 is a metabolically activated prodrug of a charged MGD.

Physicochemical Properties

M.Wt	658.16
Formula	C30H29ClFN5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (S)-2-(4-(4-(3-chloro-4-(fluorosulfonyl)benzamido)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

References

1. Zhuang Z, et al. Nat Chem Biol. 2026 Apr 6. doi: 10.1038/s41589-026-02182-5.

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