MDP5

Chemical Structure : MDP5

Catalog No.: PC-26515Not For Human Use, Lab Use Only.

MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2.

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Biological Activity

MDP5 is a potent BRD4 and PI3K dual inhibitor, exhibits strong binding to BD1 and BD2.
MDP5 significantly inhibits the proliferation in both cell lines with IC50 values of 5.57 μM and 5.14 μM, respectively.
MDP5 inhibits cell cycle progression, colony formation, and apoptosis in MB cells.
MDP5 treatment decreases target gene expression at mRNA and protein levels.
MDP5 (20 mg/kg) decreases xenograft tumor burden in MB xenograft mice.
When combined with the KRAS G12D inhibitor MRTX1133, MDP5 resensitized resistant cancer cells.

Physicochemical Properties

M.Wt	365.39
Formula	C21H19NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(2,3-dihydrobenzo[b] [1, 4] dioxin-6-yl)-2-morpholino-4H-chromen-4-one

References

1. Sethi B, et al. J Control Release. 2023 Feb;354:80-90.

2. Ghanwatkar Y, et al. Acta Biomater. 2026 Mar;212:637-654.

MDP5

Biological Activity

Physicochemical Properties

References

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