| Cat. No. |
Product Name |
Information |
| PC-63576 |
GSK8814
ATAD2/2B inhibitor
|
GSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays. |
| PC-63543 |
CBP bromodomain inhibitor 17
CBP bromodomain inhibitor
|
CBP-IN-17 is a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family. |
| PC-63487 |
GSK-340
BET BD2 inhibitor
|
GSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2) with pKd of 8.18, 7.49, 7.72 and 7.68 for BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2, respectively. |
| PC-63272 |
INCB057643
BET inhibitor
|
INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor, reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. |
| PC-63255 |
SJ830599
|
SJ830599 is a modest selective BRD2-BD2 inhibitor with IC50 of 0.61 uM, 3.3-fold selectivity over BRD2-BD1. |
| PC-63245 |
Y08060
|
Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300. |
| PC-43414 |
I-BET151
BET inhibitor
|
I-BET151 (GSK1210151A) is a potent, selective BET bromodomain inhibitor with IC50 of 0.5, 0.25 and 0.79 uM for BRD2, BRD3 and BRD4 in FP assays, shows no effect on the 23 other bromodomain proteins including MLL. |
| PC-43341 |
GSK525768A
|
GSK525768A is an enantiomer, negative control compound of I-BET762 (GSK525762A), shows no activity against BET family proteins BRD2, BRD3 and BRD4.. |
| PC-43340 |
I-BET762
BET inhibitor
|
I-BET762 (GSK-525762A, Molibresib) is a highly potent, selective inhibitor of BET family proteins BRD2, BRD3 and BRD4 with IC50 of 32.5-42.5 nM, does not interact with other bromodomain-containing proteins (BAZ2B, ATAD2, CREBBP and PCAF). |
| PC-63219 |
TRIM24 inhibitor X
TRIM24 inhibitor
|
TRIM24 inhibitor X is a potent TRIM24 bromodomain inhibitor for synthesis dTRIM24.. |
| PC-63218 |
IACS-7e
TRIM24 inhibitor
|
IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
| PC-63216 |
IACS-9571
TRIM24 inhibitor
|
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively. |
